Development of a 3D printed perfusable <i>in vitro</i> blood–brain barrier model for use as a scalable screening tool
Madison K. Royse, Martha Fowler, A. Kristen, Yufang He, Marc R. Durante, Nicole Buist, Adam Procopio, Jun Xu, Omid Veiseh
Abstract
A 3D printed hydrogel optimized for a BBB model (1) and evaluated for perfusion and ultrasound assisted transport of antibody, IgG, across the BBB (2).
Topics & Concepts
3d printedBlood–brain barrierIn vitroChemistryBiomedical engineeringUltrasoundPerfusionScalabilityComputer scienceBiophysicsNeuroscienceMedicineCentral nervous systemBiochemistryBiologyDatabaseCardiologyRadiology3D Printing in Biomedical ResearchBarrier Structure and Function StudiesNanoparticle-Based Drug Delivery