A novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway.
Po-Yuan Huang, I-An Shih, Ying‐Chih Liao, Huey‐Ling You, Ming‐Jen Lee
Abstract
promoters was also found in S462TY cells, which was further confirmed by immunoblotting. The down-regulation of these important transcriptional factors may contribute to the vulnerability of MPNST. In summary, HDAC11 inhibitor, FT895 can potentiate the tumoricidal effect of cordycepin to suppress the MPNST cell growth, which was probably mediated by the dysfunction of hippo-signaling pathway.
Topics & Concepts
Cancer researchBiologyNeurofibromaNeurofibromatosisGeneticsHippo pathway signaling and YAP/TAZNeurofibromatosis and Schwannoma CasesAxon Guidance and Neuronal Signaling