Transdermal delivery of IBU-PLGA nanoparticles with dissolving microneedle array patch
Fan Yang, Wei Wang, Jing Zhou, Zhoubing Yu, Mingwei An, Wenxuan He, Yun Xue, Fan Chen
Abstract
There are few systematic studies using microneedles to deliver ibuprofen through the skin. In this study, Ibuprofen was encapsulated in poly (lactide-co-Glycolide) (PLGA) network to form nanoparticles(IBU-NPs), then the IBU-NPs were mixed with Sodium Hyaluronate to fabricate dissolving microneedles array patch (MNP) and applied in mice model to observe its effect. In mouse model, IBU-NPs microneedles could effectively deliver ibuprofen to mice and significantly reduced the number of writhe, significantly reduced the mRNA of CGRP, COX-2, TNF–α, IL-1β, IL-6 and increased the mRNA of opioid receptor. This study introduces a rapid microneedle transdermal delivery technique for ibuprofen nanoparticles and confirms its effectiveness in terms of the mechanism of action.