Stereoselective peptide catalysis in complex environments – from river water to cell lysates

Abstract

ratio of the tertiary amide as a conformationally well-defined tripeptide that catalyzes C-C bond formations with high reactivity and stereoselectivity - regardless of the solvent and compound composition. The chemoselectivity of the tripeptide is so high that it even catalyzes reactions in cell lysates. The findings provoke the question of the potential role of peptide catalysis in nature and during the evolution of enzymes.

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