Identification of a novel BACE1 inhibitor, timosaponin A-III, for treatment of Alzheimer's disease by a cell extraction and chemogenomics target knowledgebase-guided method
Hai-Qiao Wang, Min Liu, Liang Wang, Fen Lan, Yihan Zhang, Jin-Er Xia, Zhendong Xu, Hai Zhang
Topics & Concepts
MAPK/ERK pathwayIn vivoPharmacologyChemistryWestern blotIC50Amyloid precursor proteinIn vitroBiochemistrySignal transductionBiologyAlzheimer's diseaseMedicineDiseaseInternal medicineBiotechnologyGenePhytochemical Studies and BioactivitiesMedicinal Plants and NeuroprotectionBioactive Compounds in Plants