Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition
Rou-An Chen, Wei‐Kai Wu, Suraphan Panyod, Po‐Yu Liu, Hsiao-Li Chuang, Yi‐Hsun Chen, Qiang Lyu, Hsiu-Ching Hsu, Tzu-Lung Lin, Ting‐Chin David Shen, Yu-Tang Yang, Hsin-Bai Zou, Huai‐Syuan Huang, Yu‐En Lin, Chieh‐Chang Chen, Chi‐Tang Ho, Hsin‐Chih Lai, Ming‐Shiang Wu, Cheng‐Chih Hsu, Lee‐Yan Sheen
Abstract
This study demonstrates that even with limited exposure in early life, a residual dose of tylosin might cause long-lasting metabolic disturbances by altering the gut microbiota and its metabolites. Our findings reveal that the gut microbiota is susceptible to previously ignored environmental factors.
Topics & Concepts
TylosinGut floraBiologyAntibioticsMicrobiologyImmunologyGut microbiota and healthEpigenetics and DNA MethylationPancreatitis Pathology and Treatment