Ruthenium‐Catalyzed Enantioselective Propargylic Phosphinylation of Propargylic Alcohols with Phosphine Oxides
Shiyao Liu, Yoshiaki Tanabe, Shogo Kuriyama, Ken Sakata, Yoshiaki Nishibayashi
Abstract
The development of transition metal-catalyzed enantioselective propargylic substitution reactions has gained much progress in recent years, however, no successful example with phosphorus-centered nucleophiles has yet been reported until now. Herein, we report the first successful example of ruthenium-catalyzed enantioselective propargylic substitution reactions of propargylic alcohols with diarylphosphine oxides as phosphorus-centered nucleophiles. This synthetic approach provides a new method to prepare chiral phosphorus-containing organic compounds.
Topics & Concepts
Enantioselective synthesisPhosphineRutheniumNucleophileCatalysisChemistryOrganic chemistryPhosphorusSubstitution reactionCombinatorial chemistryTransition metalAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsOrganophosphorus compounds synthesis