[Cp*IrCl<sub>2</sub>]<sub>2</sub>-Catalyzed Amidocarbonation of Olefins with Sulfoxonium Ylides toward Functionalized Isoindolin-1-ones
Qi Yang, Junxue Bai, Han Yang, Yang Yao, Yingming Yao, Jianwei Sun, Song Sun
Abstract
-catalyzed amidocarbonation of olefins with sulfoxonium ylides has been developed to generate diverse biologically important isoindolin-1-ones in high efficiency under mild reaction conditions. Mechanism studies indicated that this cascade reaction was triggered by amino-iridation of the olefin unit to generate iridacycle, followed by formal migratory insertion with sulfoxonium ylides. This newly developed method features broad substrate scopes and operational simplicity.
Topics & Concepts
ChemistrySimplicityCatalysisOlefin fiberCascadeSubstrate (aquarium)Combinatorial chemistryCascade reactionReaction conditionsStereochemistryOrganic chemistryPhysicsQuantum mechanicsChromatographyGeologyOceanographyCatalytic C–H Functionalization MethodsSynthesis and pharmacology of benzodiazepine derivativesSynthetic Organic Chemistry Methods