Ligands for Protein Fibrils of Amyloid-β, α-Synuclein, and Tau
Timothy S. Chisholm, Christopher A. Hunter
Abstract
possess disease-specific morphologies, highlighting the need for morphology-specific amyloid-binding ligands. This review details the morphologies of Aβ, tau, and αSyn fibril polymorphs that have been reported as a result of structural work and describes a database of amyloid-binding ligands containing 4,288 binding measurements for 2,404 unique compounds targeting Aβ, tau, or αSyn fibrils.
Topics & Concepts
ChemistryAmyloid fibrilFibrilAmyloid (mycology)Amyloid βBiophysicsProtein aggregationAlpha-synucleinBiochemistryParkinson's diseaseInternal medicineDiseaseBiologyMedicineInorganic chemistryAlzheimer's disease research and treatmentsParkinson's Disease Mechanisms and TreatmentsProtein Structure and Dynamics