Amphotericin B Tamed by Salicylic Acid
Yuming Yu, Peng Chen, Mingxing Gao, Wei Lan, Shijun Sun, Ziwei Ma, Rome Sultani, Yincang Cui, Muhammad Umar, Sher Wali Khan, Xiaodong Cai, Zhenjiang Liang, Hui Tan
Abstract
was significantly reduced, with almost no nephrotoxicity in the therapeutic window of the drug. At the same time, the hemolytic toxicity was significantly reduced. Therefore, modification of AmB by introducing SA is an effective strategy to maintain the broad antifungal activity of AmB and reduce its cytotoxicity. These AmB derivatives could be applied in clinical therapy in the future.
Topics & Concepts
Amphotericin BNephrotoxicityCytotoxicityToxicityCryptococcus neoformansMicrobiologyIn vitroChemistryPharmacologyCandida albicansSulforhodamine BAntifungalBiologyBiochemistryOrganic chemistryAntifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology