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Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations

Wagdy M. Eldehna, Mahmoud A. El Hassab, Mahmoud F. Abo-Ashour, Tarfah Al‐Warhi, Mahmoud M. Elaasser, Nesreen A. Safwat, Howayda Suliman, Marwa F. Ahmed, Sara T. Al‐Rashood, Hatem A. Abdel‐Aziz, Radwan El‐Haggar

2021Bioorganic Chemistry104 citationsDOI

Topics & Concepts

IsatinChemistryBenzimidazoleIn vitroApoptosisBiochemistryCombinatorial chemistryOrganic chemistrySynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activityCancer-related Molecular Pathways
Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations | Litcius