Therapeutic Potential of a Water-Soluble Silver-Diclofenac Coordination Polymer on 3D Pancreatic Cancer Spheroids
Sabina W. Jaros, Urszula K. Komarnicka, Agnieszka Kyzioł, Barbara Pucelik, Dmytro S. Nesterov, Alexander M. Kirillov, Piotr Smoleński
Abstract
induces an apoptotic pathway via reactive oxygen species generation, targeting mitochondria due to their membrane depolarization. This study broadens a group of bioactive metal-organic networks and highlights the significant potential of such compounds in developing advanced therapeutic solutions.
Topics & Concepts
ChemistryCytotoxicityCisplatinReactive oxygen speciesDiclofenacTherapeutic indexApoptosisPancreatic cancerCombinatorial chemistryPharmacologyDrugCancer researchStereochemistryIn vitroBiochemistryCancerChemotherapyBiologySurgeryInternal medicineMedicineMetal-Organic Frameworks: Synthesis and ApplicationsMetal complexes synthesis and propertiesNanoplatforms for cancer theranostics