Synaptotagmin-1 C2B domains cooperatively stabilize the fusion stalk <i>via</i> a master-servant mechanism
Ary Lautaro Di Bartolo, Diego Masone
Abstract
interactions neither through its polybasic patch nor through its pair of arginines, and in the end, losing its ability to assist the master in the formation of the fusion stalk.
Topics & Concepts
FusionLipid bilayer fusionDomain (mathematical analysis)Mechanism (biology)Fusion mechanismBiophysicsServantStalkChemistryMutantVesicle fusionMembraneProcess (computing)Cell biologyMutationNanotechnologyMaster regulatorTransmembrane domainBiological systemVesicleFusion proteinWork (physics)Cellular transport and secretionProtein Kinase Regulation and GTPase SignalingCell death mechanisms and regulation