Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy
Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He, Caicun Zhou
Abstract
Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1 (PD-L1) and interact with signaling such as cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling. Here, we review the basic knowledge of DDR pathways, mechanisms of genomic instability induced by DDR alterations, impacts of DDR alterations on immune system, and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy.
Topics & Concepts
Genome instabilityImmunotherapyStimulator of interferon genesDNA damageCancer immunotherapyCancer researchSignal transductionCancerImmune systemBiologyBiomarkerDownregulation and upregulationInterferonImmunologyGeneInnate immune systemDNACell biologyGeneticsinterferon and immune responsesCancer Immunotherapy and BiomarkersPARP inhibition in cancer therapy