Regulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review)
Zhaoping Liu, Yanyan Wang, Shunling Yuan, Feng Wen, Jing Liu, Liheng Zou, Ji Zhang
Abstract
Long non‑coding RNA metastasis‑associated urothelial carcinoma associated 1 (<em>UCA1</em>) plays a pivotal role in various human diseases. Its gene expression is regulated by several factors, including transcription factors, chromatin remodeling and epigenetic modification. <em>UCA1</em> is involved in the regulation of the PI3K/AKT, Wnt/β‑catenin, MAPK, NF‑κB and JAK/STAT signaling pathways, affecting a series of cellular biological functions, such as cell proliferation, apoptosis, migration, invasion and tumor drug resistance. Furthermore, <em>UCA1</em> is used as a novel potential biomarker for disease diagnosis and prognosis, as well as a target for clinical gene therapy. The present review systematically summarizes and elucidates the mechanisms of upstream transcriptional regulation of <em>UCA1</em>, the regulatory role of <em>UCA1</em> in multiple signaling pathways in the occurrence and development of several diseases, and its potential applications in clinical treatment.