Coriander essential oil attenuates dexamethasone-induced acute liver injury through potentiating Nrf2/HO-1 and ameliorating apoptotic signaling
Mona F. Mahmoud, Noura Ali, Ismail Mahdi, Omar Mouhtady, Islam Mostafa, Assem M. El‐Shazly, Mohamed A. O. Abdelfattah, Rehab A. Hasan, Mansour Sobeh
Abstract
Coriander essential oil extracted from the fruits of Coriandrum sativum is rich in linalool, γ-terpinene and α-pinene. Herein we examined the possible hepatoprotective effects of coriander essential oil on dexamethasone-induced liver injury and the possible mechanisms. Coriander essential oil at the doses of 0.5 and 1 mL/kg or metformin (50 mg/kg) was orally administered to rats for four days, one hour before dexamethasone subcutaneous injection. Liver injury was enhanced in dexamethasone-injected rats as manifested by monocyte infiltration, hepatocyte degeneration and collagen deposition besides elevated ALT and AST levels. This was accompanied by decreased Nrf2/HO-1 signaling, leading to increased lipid peroxidation and reduced glutathione depletion. Liver-antiapoptotic protein, Bcl2 was reduced, and caspase 3 expression was increased showing hepatocyte apoptosis following dexamethasone injection. Coriander essential oil dose-dependently reversed the previous changes. These findings suggest that coriander essential oil could ameliorate dexamethasone-induced liver injury via Nrf2/HO-1 and antiapoptotic signaling pathways.