Multicomponent Self‐Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity
Jian‐Cai Liu, Jie‐Fei Wang, Qing Han, Ping Shangguan, Lu‐Lu Liu, Lijuan Chen, Junwei Zhao, Carsten Streb, Yu‐Fei Song
Abstract
Abstract The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH 3 ) 2 ) 2 O] 4 {[CeW 5 O 18 ] [TeW 4 O 16 ][CeSn(CH 3 ) 2 ] 4 [TeW 8 O 31 ] 4 } 2 } 46− ( 1 a ) features dimensions of ca. 2.2×2.3×3.4 nm 3 and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that 1 features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of 1 and open new paths for further development of this new compound class.