Profiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity
Lin Wang, Ling Wang, Hui Zhuang
Abstract
Using high-throughput pseudovirus assay in conjunction with neutralizing antibodies, Wang et al. investigated 80 natural variants and 26 glycosylation-spike (S) mutants of SARS-CoV-2 in terms of infectivity and antigenicity. 1 They identified several mutations that can critically affect the virus infectivity and reactivity to neutralizing antibodies (Fig. This study provides abundant and comprehensive data that will help us better understand the impact of mutations in S protein, and may contribute to future design of potent vaccine candidate and monoclonal antibodies (mAbs).
Topics & Concepts
VirologyInfectivityAntigenicityVirusBiologyMonoclonal antibodyAntibodyViral entryViral replicationGeneticsSARS-CoV-2 and COVID-19 ResearchViral Infections and Outbreaks ResearchVirology and Viral Diseases