Ruthenium(II)/Chiral Carboxylic Acid Catalyzed Enantioselective C–H Functionalization of Sulfoximines
Tatsuhiko Yoshino, Shigeki Matsunaga, Long‐Tao Huang, Yuuki Hirata, Yoshimi Kato, Luqing Lin, M. Kojima
Abstract
Abstract Ruthenium(II)-catalyzed enantioselective C–H functionalization reactions of sulfoximines with sulfoxonium ylides are described. The combination of [RuCl2(p-cymene)]2 and a pseudo-C 2-symmetric binaphthyl monocarboxylic acid furnished the S-chiral products in 76:24 to 92:8 er.
Topics & Concepts
ChemistryEnantioselective synthesisRutheniumSurface modificationCatalysisCarboxylic acidOrganic chemistryCombinatorial chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms