Internal Alkyne-Directed Fluorination of Unactivated C(sp<sup>3</sup>)–H Bonds
Chenyun Shu, Jian Feng, Hanliang Zheng, Cungui Cheng, Zheliang Yuan, Zuxiao Zhang, Xiao‐Song Xue, Gangguo Zhu
Abstract
A silver-mediated internal alkyne-guided fluorination of unactivated C(sp3)–H bonds is described. The reaction provides a facile access to γ-fluorinated fluoroalkylated (Z)-alkenes from readily available alkynes in promising yields with excellent regioselectivity, stereoselectivity, and site selectivity.
Topics & Concepts
AlkyneChemistryRegioselectivityStereoselectivitySelectivityCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisFluorine in Organic ChemistryCatalytic C–H Functionalization Methods