Design, synthesis, antimicrobial screening and molecular modeling of novel 6,7 dimethylquinoxalin-2(1H)-one and thiazole derivatives targeting DNA gyrase enzyme
Raghad M. Alqurashi, Thoraya A. Farghaly, Rehab Sabour, Mohamed R. Shaabana
Topics & Concepts
DNA gyraseChemistryThiazoleAntimicrobialCiprofloxacinMinimum inhibitory concentrationIn vitroEnzymeDNAIC50StereochemistryDocking (animal)BiochemistryEscherichia coliAntibioticsOrganic chemistryMedicineNursingGeneSynthesis and Biological EvaluationSynthesis and biological activityQuinazolinone synthesis and applications