A multifunctional nano-delivery system enhances the chemo-<i>co</i>-phototherapy of tumor multidrug resistance <i>via</i> mitochondrial-targeting and inhibiting P-glycoprotein-mediated efflux
Runze Zhao, Xiaoyue Ning, Mengqi Wang, Ao Yu, Yongjian Wang
Abstract
animal experiments based on BALB/c nude mice bearing MCF-7/ADR tumors confirmed a superior antitumor efficacy and an excellent biosafety profile. These findings demonstrate that this multifunctional nanoplatform provides a new approach for the treatment of MDR tumors.
Topics & Concepts
EffluxMultiple drug resistanceP-glycoproteinNano-Cancer researchMaterials scienceNanotechnologyChemistryPharmacologyBiologyBiochemistryAntibioticsComposite materialNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesNanoparticle-Based Drug Delivery