4D Multimodal Nanomedicines Made of Nonequilibrium Au–Fe Alloy Nanoparticles
Veronica Torresan, Daniel Forrer, Andrea Guadagnini, Denis Badocco, Paolo Pastore, Maurizio Casarin, Annabella Selloni, Diego F. Coral, Marcelo Ceolı́n, M. B. Fernández van Raap, Alice Busato, Pasquina Marzola, Antonello E. Spinelli, Vincenzo Amendola
Abstract
tests show the potential of these transformable Au-Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed X-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au-Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.