Electrocatalytic Dehydrogenative Cyclization of 2-Vinylanilides for the Synthesis of Indoles
Yun‐Tao Zheng, Jinshuai Song, Hai‐Chao Xu
Abstract
Indole is prevalent in bioactive compounds and natural products. The development of efficient and sustainable methods to access this privileged structural scaffold has been a long-standing interest of synthetic chemists. Herein, we report an electrocatalytic method for the synthesis of indoles through dehydrogenative cyclization of 2-vinylanilides. The reactions employ an organic redox catalyst and do not require any external chemical oxidant, providing speedy and efficient access to 3-substituted and 2,3-disubstituted indoles.
Topics & Concepts
ChemistryIndole testCombinatorial chemistryCatalysisRedoxChemical synthesisOrganic chemistryBiochemistryIn vitroRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions