A copper(<scp>ii</scp>) peptide helicate selectively cleaves DNA replication foci in mammalian cells
Ana Alcalde-Ordóñez, Natalia Barreiro-Piñeiro, Bríonna McGorman, Jacobo Gómez‐González, David Bouzada, F. Rivadulla, M. Eugenio Vázquez, Andrew Kellett, José Martı́nez-Costas, Miguel Vázquez López
Abstract
and in mammalian cells. Since the DNA replication process is deregulated in cancer cells, this approach may pave the way for the development of a new class of anticancer agents based on copper-based artificial nucleases.
Topics & Concepts
DNANucleaseDNA replicationCell biologyChemistryDNA damageIn vitroPeptideEukaryotic DNA replicationCellBiologyBiochemistryMolecular biologyMetal complexes synthesis and propertiesDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniques