Design, synthesis and mechanism study of coumarin-sulfonamide derivatives as carbonic anhydrase IX inhibitors with anticancer activity
Qianqian Lv, Jing Zhang, Jianghong Cai, Lexian Chen, Jiajie Liang, Tianwan Zhang, Jiahui Lin, Ruiyao Chen, Zhiling Zhang, Peiting Guo, Yue Hong, Lingxue Pan, Hong Ji
Topics & Concepts
SulfonamideCoumarinCarbonic anhydraseChemistryPharmacologyCombinatorial chemistryMechanism (biology)EnzymeStereochemistryBiochemistryMedicineOrganic chemistryPhilosophyEpistemologyEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities