Newly synthesized palladium(<scp>ii</scp>) complexes with aminothiazole derivatives: <i>in vitro</i> study of antimicrobial activity and antitumor activity on the human prostate cancer cell line
Dejan Simić, Milan Zarić, Ivana Nikolić, Radica Živković Zarić, Petar Čanović, Aleksandar Kočović, Ivana D. Radojević, Ivana Raković, Sandra Jovičić Milić, D. Petrović, Danijela Lj. Stojković, Nenad Vuković, Miroslava Kačániová, Milena Vukić, Verica V. Jevtić
Abstract
indicated very good binding of all complexes to CT-DNA. Also, the new Pd(II) complexes show high cytotoxic activity towards the human prostate cancer cell line and insignificant activity towards non-cancerous human fibroblasts. Future research could additionally explore the biological activity of Pd(II) complexes presented in this paper and investigate the possibility of their implementation in clinical practice.
Topics & Concepts
PalladiumThiazoleChemistryAntimicrobialQuenching (fluorescence)Amino acidStereochemistryProton NMRNuclear chemistryFluorescenceOrganic chemistryBiochemistryCatalysisQuantum mechanicsPhysicsMetal complexes synthesis and propertiesClick Chemistry and ApplicationsSynthesis of Tetrazole Derivatives