Isorhamnetin induces cell cycle arrest and apoptosis by triggering DNA damage and regulating the AMPK/mTOR/p70S6K signaling pathway in doxorubicin-resistant breast cancer
Tianshu Yang, Yi Xiao, Shuo Liu, Fazhen Luo, Dongyun Tang, Yilin Yu, Yan Xie
Topics & Concepts
PI3K/AKT/mTOR pathwayAMPKApoptosisCell cycle checkpointCancer researchDoxorubicinDNA damageSignal transductionChemistryCell cycleIsorhamnetinCell biologyKinaseMedicineBiologyDNAProtein kinase AInternal medicineChemotherapyBiochemistryKaempferolAntioxidantQuercetinPhytochemical and Pharmacological StudiesBioactive Compounds in PlantsAgriculture and Biological Studies