Acute and chronic sympathomimetic effects of e-cigarette and tobacco cigarette smoking: role of nicotine and non-nicotine constituents
Sara Arastoo, Kacey Haptonstall, Yasmine Choroomi, Roya Moheimani, Kevin Nguyen, Elizabeth Tran, Jeffrey Gornbein, Holly R. Middlekauff
Abstract
Chronic electronic cigarette (EC) users and tobacco cigarette (TC) smokers exhibit a similar level of sympathetic nerve activity as estimated by heart rate variability. Acute increases in blood pressure (BP) and heart rate in EC users are attribute to nicotine, not non-nicotine, constituents in EC aerosol. Acute TC smoking increased BP significantly more than acute EC use, despite similar increases in plasma nicotine, suggestive of additional adverse vascular effects attributable to combusted, non-nicotine constituents in TC smoke.
Topics & Concepts
NicotineHemodynamicsHeart rateHeart rate variabilityMedicineBlood pressureInternal medicinePharmacologyCardiologyAnesthesiaEndocrinologyHeart Rate Variability and Autonomic ControlSmoking Behavior and CessationAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes