Life histories of myeloproliferative neoplasms inferred from phylogenies
N Williams, Lee J, E Mitchell, L Moore, Baxter EJ, J Hewinson, Dawson KJ, A Menzies, Godfrey AL, Green AR, Campbell PJ, J Nangalia
Abstract
Brief summary: This study performed whole-genome sequencing (WGS) of 1013 clonal haematopoietic cell colonies from 12 adult patients aged 2081 years with myeloproliferative neoplasms, a form of blood cancer. They identified 580 133 somatic mutations and used these to reconstruct haematopoietic clonal histories. Key somatic (i.e. non-germline) driver mutations were estimated to have occurred early in life, including fetal life and early childhood.
Topics & Concepts
Somatic cellGermlineBiologyHaematopoiesisGermline mutationGeneticsMutationGeneStem cellMyeloproliferative Neoplasms: Diagnosis and TreatmentChronic Myeloid Leukemia TreatmentsAcute Myeloid Leukemia Research