Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway
Yiyi Zhang, Lijun Sun, Yanwu Sun, Ying Chen, Xiaojie Wang, Meifang Xu, Pan Chi, Zongbin Xu, Xingrong Lu
Topics & Concepts
Downregulation and upregulationBiologyGene knockdownCarboxylesteraseCancer researchPI3K/AKT/mTOR pathwayLY294002Cell cultureApoptosisSignal transductionMolecular biologyActivator (genetics)GeneCell biologyEnzymeGeneticsBiochemistryCancer therapeutics and mechanismsCancer Treatment and PharmacologyCholinesterase and Neurodegenerative Diseases