Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using <sup>1</sup>H NMR Spectroscopy
Jack E. Bramham, Adrian Podmore, Stephanie A. Davies, Alexander P. Golovanov
Abstract
H NMR spectroscopy can thus provide a holistic overview of biopharmaceutical formulation content and stability, providing a preliminary characterization of degradation and acting as a triaging step to guide further analytical techniques.
Topics & Concepts
BiopharmaceuticalNuclear magnetic resonance spectroscopyExcipientChemistrySmall moleculeProtein stabilitySpectroscopyMoleculeFragmentation (computing)Relaxation (psychology)ChromatographyOrganic chemistryBiochemistryComputer scienceOperating systemPsychologyQuantum mechanicsSocial psychologyBiologyPhysicsGeneticsProtein purification and stabilityMonoclonal and Polyclonal Antibodies ResearchViral Infectious Diseases and Gene Expression in Insects