Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25
Qiuyang Zheng, Guilin Li, Shihua Wang, Ying Zhou, Ke Liu, Yue Gao, Yulin Zhou, Liangkai Zheng, Lin Zhu, Qingfang Deng, Meiling Wu, Anjie Di, Lishan Zhang, Yingjun Zhao, Hongfeng Zhang, Hao Sun, Chen Dong, Huaxi Xu, Xin Wang
Abstract
Trisomy 21 induces microglial dysregulation in the Alzheimer’s brain through the perturbation of the ubiquitin-proteasome system.
Topics & Concepts
NeuroinflammationMicrogliaChromosome 21TrisomyNeuroscienceProinflammatory cytokineNeurodegenerationBiologyDYRK1ADown syndromeImmunologyMedicineGeneticsInflammationChromosomeDiseaseGeneInternal medicineNeuroinflammation and Neurodegeneration MechanismsUbiquitin and proteasome pathwaysAlzheimer's disease research and treatments