Inactivation of the riboswitch-controlled GMP synthase GuaA in <i>Clostridioides difficile</i> is associated with severe growth defects and poor infectivity in a mouse model of infection
Erich Smith-Peter, David Lalonde Séguin, Émilie St-Pierre, Ognjen Sekulović, Simon Jeanneau, Cédrick Tremblay-Tétreault, Anne-Marie Lamontagne, Pierre‐Étienne Jacques, Daniel A. Lafontaine, Louis‐Charles Fortier
Abstract
during infection, suggesting that targeting guanine riboswitches with analogues could be a viable therapeutic strategy.
Topics & Concepts
RiboswitchBiologyGuanineGuanosineRNAMicrobiologyBiochemistryGeneNucleotideNon-coding RNAClostridium difficile and Clostridium perfringens researchAntimicrobial Resistance in StaphylococcusViral gastroenteritis research and epidemiology