A Unified, Microwave‐Assisted, Palladium‐Catalyzed Regioselective Ortho‐monohalogenation of 1‐Alkyl/benzyl‐3‐Phenylquinoxalin‐2(1 <i>H</i> )‐ones
Sandeep Kumar, Prince Prince, Monika Monika, Prashant Kumar, Christophe Len, Brajendra K. Singh
Abstract
Abstract A Unified, Microwave assisted, Pd‐catalyzed regioselective ortho ‐monohalogenation of 3‐phenylquinoxalin‐2(1 H )‐one derivatives has been disclosed using readily available N ‐halosuccinimides (NXS). The nitrogen atom of quinoxalin‐2(1 H )‐one facilitated as an effective directing group and helped in achieving regioselective mono halogenation at ortho ‐position of 3‐phenyl ring of 3‐phenylquinoxalin‐2(1 H )‐ones. Under mild reaction condition, a wide diversity of mono halogenated products were obtained with wide substrate scope and high functional group tolerance in good yields. Post‐functionalization of the synthesized molecules has been demonstrated.