Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression
Ming Li, Yuan Deng, Minghui Zhuo, Hui Zhou, Xu Kong, Xiaogang Xia, Zhaojie Su, Qiang Chen, Peng Guo, Pingli Mo, Chundong Yu, Wengang Li
Abstract
Our study demonstrates that JMJD2D can antagonize the tumor suppressor p53 and activate an oncogenic signaling pathway (such as Wnt/β-catenin signaling pathway) simultaneously to promote liver cancer initiation and progression, suggesting that JMJD2D may serve as a novel target for liver cancer treatment.
Topics & Concepts
DemethylaseFunction (biology)AntagonistCancerCancer researchLiver cancerMedicineNeurosciencePharmacologyChemistryBiologyComputational biologyInternal medicineCell biologyReceptorBiochemistryGeneEpigeneticsEpigenetics and DNA MethylationCancer-related Molecular PathwaysAutophagy in Disease and Therapy