Copper‐catalyzed multicomponent green reaction approach: Synthesis of dihydropyrano [2,3‐c] pyrazoles and evaluation of their anti‐cancer activity
Venkata Hema Kumar, Ramana Tamminana
Abstract
Abstract A facile, efficient, and simple one‐pot multi‐component protocol for the synthesis of pyrano[2,3‐c] pyrazoles has been developed using a cheap and readily available copper catalyst under moderate reaction conditions. Target products are obtained from aromatic aldehyde via Knoevenagel condensation and Michael addition reactions. Functional group tolerance and reaction mechanisms have also been examined in this methodology. In addition, we have also evaluated the anti‐cancer activity of the target products and we have attempted this method for practical utility purposes also.
Topics & Concepts
ChemistryKnoevenagel condensationAldehydeCatalysisCondensation reactionCopperCombinatorial chemistryPyrazoleOrganic chemistryReaction conditionsMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Biological Evaluation