Cooperation between the Cu <sup>+</sup> and Cu <sup>2+</sup> species in CuCoAl layered double hydroxide and the substrate promoting effect afford a really simple protocol for the efficient synthesis of quinazolines
Xue Zhou, Fei Qian, Weiyou Zhou, Anwei Wang, Tao Hou, Xiaoting Tian, Shuliang Ji, Ming‐Yang He, Junfeng Qian
Abstract
species in CuCoAl-LDH was observed in the cascade reaction, and they are believed to be responsible for the oxidation of alcohol and dehydrogenation of the intermediate, respectively. The promoting effect of the substrate diamine was observed in the oxidation of alcohol, which simplifies the reaction system by eliminating the requirement for a base additive. The catalytic system exhibited highly practical potential for the synthesis of quinazolines, as demonstrated through recyclability investigations and scale-up experiments. A possible catalytic mechanism has been proposed based on a series of control experiments and EPR analysis.
Topics & Concepts
HydroxideProtocol (science)CascadeCatalysisSubstrate (aquarium)Simple (philosophy)AlcoholCombinatorial chemistryChemistryOrganic chemistryChromatographyEpistemologyPathologyMedicinePhilosophyOceanographyGeologyAlternative medicineQuinazolinone synthesis and applicationsAsymmetric Hydrogenation and CatalysisNanomaterials for catalytic reactions