Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: <i>in silico</i> and <i>in vitro</i> studies
Aamir Aman, Saba Ali, Panupong Mahalapbutr, Kuakarun Krusong, Peter Wolschann, Thanyada Rungrotmongkol
Abstract
. Taken together, our results suggest that the modified CDs, particularly SBEβCD, hold promising potential as an efficient molecular encapsulating agent for SOR, offering improved solubility and stability for this lipophilic drug.
Topics & Concepts
In silicoSolubilityChemistryCyclodextrinIn vitroSorafenibInclusion (mineral)Combinatorial chemistryStability (learning theory)ChromatographyComputational chemistryStereochemistryOrganic chemistryBiochemistryComputer scienceMedicineMineralogyCancer researchGeneHepatocellular carcinomaMachine learningDrug Solubulity and Delivery SystemsEnzyme Structure and FunctionDrug Transport and Resistance Mechanisms