Microcavity array supported lipid bilayer models of ganglioside – influenza hemagglutinin<sub>1</sub> binding
Guilherme B. Berselli, Nirod Kumar Sarangi, Aurélien V. Gimenez, Paul V. Murphy, Tia E. Keyes
Abstract
The binding of influenza receptor (HA1) to membranes containing different glycosphingolipid receptors was investigated at Microcavity Supported Lipid Bilayers (MSLBs). We observed that HA1 preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA1 GM1 or GM3.
Topics & Concepts
Hemagglutinin (influenza)Lipid bilayerBilayerGangliosideChemistryBiophysicsVirologyNanotechnologyMaterials scienceBiochemistryBiologyMembraneGeneLipid Membrane Structure and BehaviorAdvanced Fluorescence Microscopy TechniquesMechanical and Optical Resonators