Live <i>Lactobacillus acidophilus</i> alleviates ulcerative colitis <i>via</i> the SCFAs/mitophagy/NLRP3 inflammasome axis
Pei Li, Guoping Chen, Jiaxian Zhang, Chaoying Pei, Ying Chen, Jing Gong, Song Deng, Kaiwei Cai, Haiyan Li, Dawei Wang, Baochun Shen, Zhiyong Xie, Qiongfeng Liao
Abstract
The live Lactobacillus acidophilus (La) alleviated colitis by ameliorating intestinal barrier and suppressing inflammation. SCFAs modulated and enriched by La promoted the mitophagy/NLRP3 inflammasome pathway, which helped to improve gut functions.
Topics & Concepts
Lactobacillus acidophilusInflammasomeMitophagyUlcerative colitisAutophagyProbioticDysbiosisImmune systemColitisInflammationBiologyMicrobiologyImmunologyChemistryMedicineGut floraBacteriaDiseaseBiochemistryInternal medicineGeneticsApoptosisInflammasome and immune disordersAutophagy in Disease and TherapyGut microbiota and health