The Impact of Insulin Resistance on Cardiovascular Control During Exercise in Diabetes
Masaki Mizuno, Norio Hotta, Rie Ishizawa, Han‐Kyul Kim, Gary A. Iwamoto, Wanpen Vongpatanasin, Jere H. Mitchell, Scott A. Smith
Abstract
Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.
Topics & Concepts
HyperinsulinemiaInsulin resistanceDiabetes mellitusMedicineInternal medicineEndocrinologyMechanism (biology)InsulinBlood pressureEpistemologyPhilosophyHeart Rate Variability and Autonomic ControlCardiovascular and exercise physiologyAdipose Tissue and Metabolism