Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216
Thomas R. Cotton, Simon A. Cobbold, Jonathan P. Bernardini, Lachlan W. Richardson, Xiangyi S. Wang, Bernhard C. Lechtenberg
Topics & Concepts
Ubiquitin ligaseUbiquitinBiologyDNA ligaseCell biologyDeubiquitinating enzymeMutationBiochemistryCell division control protein 4GeneticsGeneUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyCellular transport and secretion