A mitochondria-targeted far-red AIE fluorescent probe for distinguishing between mitophagy and ferroptosis in cancer cells
Liyuan Sun, Mengfei Zou, Longjie Du, Shugang Wang, Ru Ding, Keliang Lu, Jianchun Li, Jin Zhou
Abstract
A mitochondria-targeted far-red fluorescent probe LY-1 with AIE character was formulated to track cell viscosity alterations with excellent sensitivity and selectivity, which was used to discriminate between mitophagy and ferroptosis in cancer cells. Probe LY-1 is expected to be an effective vehicle for the diagnosis of mitochondrial viscosity relevant diseases.
Topics & Concepts
MitophagyFluorescenceMitochondrionCancer cellBiophysicsChemistryCell biologyCancerNanotechnologyBiologyMaterials scienceBiochemistryAutophagyApoptosisGeneticsPhysicsOpticsAdvanced biosensing and bioanalysis techniquesFerroptosis and cancer prognosisDrug Transport and Resistance Mechanisms