Axons-on-a-chip for mimicking non-disruptive diffuse axonal injury underlying traumatic brain injury
Xiaorong Pan, Jie Li, Wei Li, Haofei Wang, Nela Durisic, Zhenyu Li, Yu Feng, Yifan Liu, Chun‐Xia Zhao, Tong Wang
Abstract
surge occurs during the flux. Surprisingly, periodic axonal cytoskeleton disruption also occurs rapidly after the flux. These instant injury responses are spatially restricted to the fluxed axon, not affecting the overall viability of the neuron in the acute stage. Compatible with high-resolution live microscopy, the AoC provides a versatile system to identify early mechanisms underlying DAI, offering a platform for screening effective treatments to alleviate TBI.
Topics & Concepts
Traumatic brain injuryDiffuse axonal injuryNeuroscienceMedicineTraumatic injuryBiologySurgeryPsychiatryNeuroscience and Neural EngineeringNeurological disorders and treatments3D Printing in Biomedical Research