Recyclable rhodium-catalyzed C–H activation/[4 + 2] annulation with unconventional regioselectivity at ambient temperature: experimental development and mechanistic insight
Haifang Meng, Huiying Xu, Zhi Zhou, Zhenhao Tang, Yidi Li, Yu Zhou, Wei Yi, Xiaowei Wu
Abstract
A robust and convenient rhodium-catalyzed unconventionally regioselective C–H activation/[4 + 2] annulation for the synthesis of isoquinolones which are prevalent in natural products and pharmaceuticals was developed.
Topics & Concepts
AnnulationRegioselectivityRhodiumCatalysisChemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms