Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection
Dominik Alterauge, Johannes Bagnoli, Frank Dahlström, Barry Bradford, Neil A. Mabbott, Thorsten Buch, Wolfgang Enard, Dirk Baumjohann
Abstract
Tfh cells. In contrast, continued Bcl6 expression is critical to maintain the GC Tfh cell phenotype and also the GC reaction. Importantly, Bcl6 ablation during acute viral infection results in the transdifferentiation of established Tfh into Th1 cells, thus highlighting the plasticity of Tfh cells. These findings have implications for strategies that boost or restrain Tfh cells and GCs in health and disease.
Topics & Concepts
BCL6CXCR5Germinal centerTransdifferentiationBiologyTranscription factorCell biologyImmunologyAntibodyB cellGeneStem cellGeneticsImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses