Bioactive compounds from <i>Physalis angulata</i> and their anti-inflammatory and cytotoxic activities
Hoang Le Tuan Anh, Vinh Le Ba, Đỗ Thị Thảo, Van Kiem Phan, Hai Yen Pham Thi, Long Giang Bạch, Manh Hung Tran, Phuong Anh Tran Thi, Young Ho Kim
Abstract
A new compound, physalucoside A (1), together with seven withanolides (2–8) and three flavonoids (9–11), were isolated from Physalis angulata L. (Solanaceae), a medicinal plant native to Vietnam. The chemical structures of these compounds were elucidated by one- and two-dimensional NMR spectra, high-resolution electrospray ionization mass spectrometry analyses, and chemical reactivity. The anti-inflammatory and cytotoxic activities of isolated compounds were also evaluated. These data suggest that the anti-inflammatory activity of P. angulata is due primarily to its withanolide content. This study demonstrates the potential of withanolides as promising candidates for the development of new anti-inflammatory drugs.