Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells
Jin Zhang, Ling Zou, Pan Tang, Dabo Pan, Zhendan He, Dahong Yao
Topics & Concepts
ChemistryApoptosisIC50Protein kinase BPAK1Cell growthKinaseCell biologySignal transductionCell migrationCellCancer researchBiochemistryIn vitroBiologyCell death mechanisms and regulationProtein Kinase Regulation and GTPase SignalingFOXO transcription factor regulation