Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1
Nicolas Vabret, Valérie Najburg, Alexander Solovyov, Ramya Gopal, Christopher B. McClain, Petr Šulc, Sreekumar Balan, Yannis Rahou, Guillaume Beauclair, Maxime Chazal, Hugo Varet, Rachel Legendre, Odile Sismeiro, Raul Y. Sanchez-David, Lise Chauveau, Nolwenn Jouvenet, Martin Markowitz, Sylvie van der Werf, Olivier Schwartz, Frédéric Tangy, Nina Bhardwaj, Benjamin D. Greenbaum, Anastassia V. Komarova
Abstract
, inducing a transcriptome-wide change of cellular RNA 5'-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection.
Topics & Concepts
RNAEndogenyVirologyHuman immunodeficiency virus (HIV)BiologyVirusComputational biologyGeneticsGeneBiochemistryinterferon and immune responsesViral Infections and Immunology ResearchRNA and protein synthesis mechanisms